Publications From NITC

1. Punya V P,^⸸ Neethu Mariam Thomas,^⸸ Ranjith Kumavath, Venkanna Muripiti, Janardhan Banothu*. Pyrimidine Derivatives as Anti-HIV Agents: Advances and Structure–Activity Relationship Insights. Journal of Molecular Structure 2026 (Accepted). ^⸸These authors have equal contributions

2. Munugala Chandrakanth, Jyothi Kumari, Sonam Bisla, Mukesh Pasupuleti, Ramesh Gondru, Jesu Arockiaraj, Dharmarajan Sriram,* Janardhan Banothu**. Design, Synthesis, and Identification of Benzimidazole–Acrylonitriles, Coumarin–Benzimidazole/Benzothiazole Hybrids as Potential Antitubercular Agents. Journal of Molecular Structure 1367 (2026) 146149. https://doi.org/10.1016/j.molstruc.2026.146149.

3. Neethu Mariam Thomas, Anoop Kallingal, Natalia Maciejewska, Munugala Chandrakanth, Deepak B. Salunke, Nikolai Petrovsky, Varun Thachan Kundil, Abhithaj J, Majed Alharbi, Magdalena Narajczyk, Ramesh Gondru, Catherine Healthina Pasangha, Janardhan Banothu*. Discovery of 1,2-Dihydro-4-hydroxy-2-oxoquinoline-3-carboxamide Derivatives as Potent Anticancer Agents: Structure-Based Design, Synthesis, Mechanistic Insights, Target Identification, and Molecular Docking Studies. Bioorganic Chemistry 175 (2026) 109783. https://doi.org/10.1016/j.bioorg.2026.109783.

4. Munugala Chandrakanth,  Ayswarya Mukharjee,   Krishnan Rathinasamy,   P. Chinna Ayya Swamy,* Janardhan Banothu*. Unveiling aggregation-induced emission in benzimidazole–acrylonitriles for fluorescence live-cell imaging in HeLa cells. Journal of Materials Chemistry B 14 (2026) 3869. https://doi.org/10.1039/D5TB02419F.

5. Munugala Chandrakanth, Yoshikazu Honda-Okubo, Arya C. G., Deepak B. Salunke, Nikolai Petrovsky,* Janardhan Banothu*. Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential human toll-like receptor (TLR2) agonists: design, synthesis, and structure–activity relationship enabling the switch from TLR2/1 to TLR2/6 activation. RSC Medicinal Chemistry 17 (2026) 2886. https://doi.org/10.1039/D5MD01078K. Published with a cover artwork

6. Munugala Chandrakanth, Fabitha K, Chinna Ayya Swamy P,* Janardhan Banothu.* Tunable Aggregation-Induced Emission to Aggregation-Caused Quenching Transition in Benzimidazole–Acrylonitrile Luminogens: Experimental and Theoretical Insights. New Journal of Chemistry 50 (2026) 3026. https://doi.org/10.1039/D5NJ04441C.

7. Munugala Chandrakanth, Jyothi Kumari, Paramita Pakhira, Dharmarajan Sriram, Siddhardha Busi, Sampathkumar Ranganathan, Chandni Kumari, Sonam Bisla, Mukesh Pasupuleti,  Ramesh Gondru, Jesu Arockiaraj, Janardhan Banothu*. 2-Aminothiophene and 2-Aminothiazole Scaffolds as Potent Antimicrobial Agents: Design, Synthesis, Biological Evaluation, and Computational Insights. Bioorganic Chemistry 170 (2026) 109511. https://doi.org/10.1016/j.bioorg.2026.109511.

8. Munugala Chandrakanth, Sehal Mishra, Kankipati Gayathri, Rajasekhara Reddy Katreddy, Arya C G, Ramesh Gondru, Subbiah Rajasekaran,* Janardhan Banothu**. Fused Thiophene – Benzimidazole Conjugates Targeting EGFR: Design, Synthesis, Anticancer Evaluation and their Mechanistic Insights. European Journal of Medicinal Chemistry, 303 (2026) 118435. https://doi.org/10.1016/j.ejmech.2025.118435.

9. C. G. Arya, Neethu Mariam Thomas, Munugala Chandrakanth, Anoop Kallingal, P. G. Amrutha, M. S. Sivapriya, Ramesh Gondru, Janardhan Banothu*. Coumarin – Benzimidazole Hybrids: Design, Synthesis and Identification of Potential Anticancer Agents. Bioorganic & Medicinal Chemistry Letters, 131 (2026) 130444. https://doi.org/10.1016/j.bmcl.2025.130444.

10. K. Fabitha, Munugala Chandrakanth, Anoop Kallingal, Natalia Maciejewska, Praveen Telukuntla, Ramesh Gondru, Ranjith Kumavath, T.D. Demina, Majed Alharbi, Janardhan Banothu*. Identification of pyrazole-acrylonitrile derivatives as potential anticancer agents and mechanistic insights. Bioorganic & Medicinal Chemistry, 130 (2025) 118352. https://doi.org/10.1016/j.bmc.2025.118352.

11. K. Fabitha, Anoop Kallingal, Natalia Maciejewska, Hiba Haneefa P. T., Varun Thachan Kundil, Majed Alharbi, Janardhan Banothu*. Improved anti-breast cancer activity through structural modification of fused pyran derivatives and mechanistic investigations. RSC Medicinal Chemistry, 16 (2025) 3671. https://doi.org/10.1039/D5MD00161G.

12. Arya C. G., Jyothi Kumari, Siddhardha Busi, Simi Asma Salim, Munugala Chandrakanth, Dharmarajan Sriram*, Ramesh Gondru, Janardhan Banothu*. Design, synthesis and antimycobacterial evaluation of benzimidazole-thiazolylhydrazone derivatives: In silico molecular docking studies, DFT analysis and ADMET predictions. Synthetic Communications, 55 (2025) 758–773. https://doi.org/10.1080/00397911.2025.2498535.

13. Arya C G, Jyothi Kumari, Jai Kishan, Kamini, Dharmarajan Sriram, Simi Asma Salim, Paramita Pakhira, Siddhardha Busi, Majed Alharbi, Munugala Chandrakanth, Mukesh Pasupuleti*, Janardhan Banothu*. 2-Substituted and 1,2-Disubstitued Benzimidazole Derivatives: Synthesis and Identification of Potential Antibacterial Agents. Journal of Molecular Structure, 1333 (2025) 141693. https://doi.org/10.1016/j.molstruc.2025.141693

14. Neethu Mariam Thomas, Majed Alharbi, Venkanna Muripiti, Janardhan Banothu*. Quinoline and quinolone carboxamides: A review of anticancer activity with detailed structure–activity relationship analysis. Molecular Diversity, 2025. https://doi.org/10.1007/s11030-024-11092-4.

15. Ashok Kumar Madikonda, Amritha Ajayakumar, Sudeena Nadendla, Janardhan Banothu, Venkanna Muripiti.* Esterase-responsive nanoparticles (ERN): A targeted approach for drug/ gene delivery exploits. Bioorganic & Medicinal Chemistry, 116 (2024) 118001. https://doi.org/10.1016/j.bmc.2024.118001.

16. Rajitha Gali, Janardhan Banothu, Punam Salaria, N. N. Subrahmanyeswara Rao, Santhosh Kumar Badampudi*. Fused Thiazolo[2,3,-b]quinazolinone-Chromone Hybrids: Synthesis, Characterization, In Vitro Antibacterial Activity and In Silico Screening. Journal of Heterocyclic Chemistry, 61 (2024) 1642-1652. https://doi.org/10.1002/jhet.4892.

17. C G Arya, Raj Kishore, Pooja Gupta, Ramesh Gondru, Jesu Arockiaraj, Mukesh Pasupuleti,* Munugala Chandrakanth, Punya V P, Janardhan Banothu*. Identification of Benzimidazole-Coumarin Hybrids as Potential Antibacterial Agents: Synthesis, in vitro and in vivo Biological Assessment, and ADMET Prediction. Bioorganic & Medicinal Chemistry Letters, 110 (2024) 129881. https://doi.org/10.1016/j.bmcl.2024.129881.   

18. Praveen Telukuntla, Munugala Chandrakanth, Amrutha P G, Neethu Mariam Thomas, Ramesh Gondru, Krishna Reddy Valluru,* Janardhan Banothu*. 1,2,3-Triazole – [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine Hybrids: A Switch for Improvement of Antibreast Cancer Activity Targeting Epidermal Growth Factor Receptor. Tetrahedron Letters, 146 (2024) 155180. https://doi.org/10.1016/j.tetlet.2024.155180.    

19. Venkanna Muripiti,* Venkatesh Ravula, Srinivas Batthula, Janardhan Banothu, Ramesh Gondru*. Phenylboronic acid-derived nanovectors for gene/ drug delivery by targeting cell surface glycans. RSC Pharmaceutics, 1 (2024) 403–411 (Published with cover art). https://doi.org/10.1039/D4PM00005F.

20. K. Fabitha, Anoop Kallingal, Natalia Maciejewska, C. G. Arya, Munugala Chandrakanth, Neethu Mariam Thomas, Yupeng Li, Ramesh Gondru, Manne Munikumar, Janardhan Banothu*. Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines. New Journal of Chemistry, 48 (2024) 8038–8054 (Published with cover art). https://doi.org/10.1039/D4NJ00824C.

21. P.G. Amrutha, Sonyanaik Banoth, Janardhan Banothu*. Neuroimmunomodulatory properties of laquinimod. Brain Disorders, 13 (2024) 100119. https://doi.org/10.1016/j.dscb.2024.100119.

22. C.G. Arya, Munugala Chandrakanth, K. Fabitha, Neethu Mariam Thomas, Bhargava Sai Allaka, Srinivas Basavoju, Sonyanaik Banoth, Janardhan Banothu*. Sodium fluoride-assisted, solvent-controlled regioselective synthesis of 2-substituted and 1,2-disubstituted benzimidazoles with diverse substituents, and unveiling mechanistic insights. Journal of Molecular Structure, 1306 (2024) 137935. https://doi.org/10.1016/j.molstruc.2024.137935.

23. Venkanna Muripiti,* Amarnath Velidandia, Yash Paul Sharma, Ramesh Gondru, C.G. Arya, Janardhan Banothu*. Targeted gene delivery through receptors with lipid nanoparticles. Journal of Drug Delivery Science and Technology, 93 (2024) 105457. https://doi.org/10.1016/j.jddst.2024.105457.

24. Munugala Chandrakanth, Neethu Mariam Thomas, Arya C G, Fabitha K, Janardhan Banothu*. Coumarin–1,2,4-triazole hybrids: Recent advances in synthesis and medicinal applications. Journal of Molecular Structure, 1299 (2024) 137197. https://doi.org/10.1016/j.molstruc.2023.137197.

25. A. P. Naseer, P. K. Madhavan Unni*, Janardhan Banothu. Light scattering investigations in the system methyl ethyl ketone + water + secondary butyl alcohol with traces of potassium thiocyanate. Journal of Molecular Liquids, 383 (2023) 383, 122081. https://doi.org/10.1016/j.molliq.2023.122081.

26. Fabitha K, Arya C G, Munugala Chandrakanth, Janardhan Banothu*. One-pot Multicomponent Green Chemistry Approach: Sodium Fluoride-Catalysed Highly Efficient Microwave Irradiation-Assisted Synthesis of Substituted Chromene Derivatives in Aqueous Medium. Research on Chemical Intermediates, 49 (2023) 997–1014. https://doi.org/10.1007/s11164-022-04929-w.

27. Arya C G, Munugala Chandrakanth, Fabitha K, Neethu Mariam Thomas, Rakendu N Pramod, Ramesh Gondru,* Janardhan Banothu*. Coumarin - Benzimidazole Hybrids: A Review on Diverse Synthetic Strategies. Results in Chemistry, 4 (2022) 100631. https://doi.org/10.1016/j.rechem.2022.100631.

28. Fabitha K, Arya C G. Shyam Perugu, Ramesh Gondru, Janardhan Banothu*. 1,2,3-Triazole linked Chalcone-Morpholine hybrids: Synthesis, in vitro Antibacterial Evaluation and in silico ADMET Predictions. Polycyclic Aromatic Compounds, 43 (2023) 7093-7109, https://doi.org/10.1080/10406638.2022.2130369.

29. K. Fabitha, Munugala Chandrakanth, Rakendu N. Pramod, C. G. Arya, Yupeng Li, Janardhan Banothu*. Recent Developments in the Synthesis of Indole-Pyrazole Hybrids. ChemistrySelect, 7 (2022) e202201064. https://doi.org/10.1002/slct.202201064.

30. Arya C G, Ramesh Gondru, Yupeng Li*, Janardhan Banothua*. Coumarin–Benzimidazole Hybrids: A Review of Developments in Medicinal Chemistry. European Journal of Medicinal Chemistry, 227 (2022) 113921. https://doi.org/10.1016/j.ejmech.2021.113921.

31. Ramesh Gondru, Sirisha Kanugala, Sneha Raj, C Ganesh Kumar, Mukesh Pasupuleti,* Janardhan Banothu, Rajitha Bavantula*. 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. Bioorganic & Medicinal Chemistry Letters, 33 (2021) 127746. https://doi.org/10.1016/j.bmcl.2020.127746.

32. Rajitha Deshineni, Arya C G, Janardhan Banothu*, Ravibabu Velpula, Gyanakumari Chellamella*. Synthesis, anticancer and antibacterial evaluation of novel 1,3-disubstituted-1H-pyrazole-4-yl-methylene embedded fused thiazolo[2,3-b]quinazolinones. Chemical Data Collections, 30 (2020) 100546. https://doi.org/10.1016/j.cdc.2020.100546.

33. G. Rajitha, C. G. Arya, B. Janardhan*, S. V. Laxmi, G. Ramesh, U. Sujana Kumari. 3-Aryl/heteryl-5-phenylindeno[1,2-d]thiazolo[3,2-a]pyrimidin-6(5H)-ones: Synthesis, characterization and antimicrobial investigation. Russian Journal of Bioorganic Chemistry, 46(4) (2020) 612-619. https://doi.org/10.1134/S106816202004007X.

Publications from Ph.D. and Post-Doc.

1. Ziwei Hu, Janardhan Banothu, Mallesh Beesu, Collin J. Gustafson, Michael J. H. Brush, Kathryn L. Trautman, Alex C. D. Salyer, Balaji Pathakumari, and Sunil A. David*. Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides. ACS Med. Chem. Lett., 2019, 10, 132−136. (First three authors have equal contributions). https://doi.org/10.1021/acsmedchemlett.8b00540 

2. Janardhan Banothu, Rajitha Gali, Ravibabu Velpula, Rajitha Bavantula*. Brønsted acidic ionic liquid catalyzed an efficient and eco-friendly protocol for the synthesis of 2,4,5-trisubstituted-1H-imidazoles under solvent-free conditions. Arab. J. Chem., 2017, 10, S2754–S2761. https://doi.org/10.1016/j.arabjc.2013.10.022 

3. B. Janardhan, B. Rajitha*, Peter A. Crooks. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient and recyclable Bronsted acid catalyst for the synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones. J. Saudi Chem. Soc., 2016, 20, S221–S226. https://doi.org/10.1016/j.jscs.2012.10.007

4. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Rajitha Bavantula*. Synthesis of novel fused thiazolo[3,2-a]pyrimidin-3-ols and evaluation for their antibacterial activity. J. Heterocycl. Chem., 2016, 53, 51-55. https://doi.org/10.1002/jhet.2281

5. Ramesh Gondru, Janardhan Banothu, Ranjith Kumar Thatipamula, Althaf Hussain SK, Rajitha Bavantula*. 3-(1-Phenyl-4-((2-(4-arylthiazol-2-yl)hydrazono)-methyl)-1H-pyrazol-3-yl)-2H-chromen-2-ones: one-pot three component condensation, in vitro antimicrobial, antioxidant and molecular docking studies. RSC Adv., 2015, 5, 33562-33569. https://doi.org/10.1039/C5RA04196A 

6. Rajitha Gali, Janardhan Banothu, Ramesh Gondru, Rajitha Bavantula*, Yashodhara Velivela, Peter A. Crooks. One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies. Bioorg. Med. Chem. Lett., 2015, 25, 106–112. https://doi.org/10.1016/j.bmcl.2014.10.100 

7. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Rajitha Deshineni, Rajitha Bavantula*. 1-Sulfopyridinium chloride: Green and expeditious ionic liquid for the one-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones under solvent free conditions. Chin. Chem. Lett., 2015, 26, 309–312. https://doi.org/10.1016/j.cclet.2014.11.030

8. Janardhan Banothu, Srinivas Basavoju, Rajitha Bavantula*. Pyridinium ylide assisted highly stereoselective one-pot synthesis of trans-2-(4-chlorobenzoyl)-3-aryl-spiro [cyclopropane-1,2′-inden]-1′,3′-diones and their antimicrobial and nematicidal activities. J. Heterocycl. Chem., 2015, 52, 853-860. https://doi.org/10.1002/jhet.2059

9. Rajitha Gali, Janardhan Banothu, Rajitha Bavantula*. One-pot multicomponent synthesis of novel substituted imidazo[1,2-a]pyridine incorporated thiazolylcoumarins and their antimicrobial activity. J. Heterocycl. Chem., 2015, 52, 641-646. https://doi.org/10.1002/jhet.2116 

10. Gondru Ramesh, Banothu Janardhan, Bavantula Rajitha*. Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation. Res. Chem. Intermed., 2015, 41, 8099–8109. https://doi.org/10.1007/s11164-014-1879-z

11. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Yakaiah Sargam, Rajitha Bavantula*. One pot and solvent-free synthesis of 3-(9-hydroxy-3-methoxy-7-aryl-6,7,9,10-tetrahydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9-yl)-2H-chromen-2-ones and their antibacterial evaluation. Turk. J. Chem., 2015, 39, 620 – 629. https://doi.org/10.3906/kim-1410-64

12. Janardhan Banothu, Manjulatha Khanapur, Srinivas Basavoju, Rajitha Bavantula*, Muralikrishna Narra, Sadanandam Abbagani. Synthesis, characterization and biological evaluation of fused thiazolo[3,2-a]pyrimidine derivatives. RSC Adv., 2014, 4, 22866-22874. https://doi.org/10.1039/C4RA02514H

13. Rajitha Gali, Janardhan Banothu, Mahendar Porika, Ravibabu Velpula, Rajitha Bavantula* Sadanandam Abbagani. Synthesis and in vitro cytotoxic activity of novel coumarinylimidazo[2,1-b]thiazole derivatives. RSC Adv., 2014, 4, 53812-53819. https://doi.org/10.1039/C4RA11428K

14. Rajitha Gali, Janardhan Banothu, Mahendar Porika, Ravibabu Velpula, Sairengpuii Hnamte, Rajitha Bavantula*, Sadanandam Abbagani, Siddhardha Busi. Indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones: Synthesis, characterization and evaluation of anticancer and antimicrobial activities. Bioorg. Med. Chem. Lett., 2014, 24, 4239–4242. https://doi.org/10.1016/j.bmcl.2014.07.030

15. Janardhan Banothu, Srinivas Basavoju, Rajitha Bavantula*, Peter A. Crooks. Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks. Tetrahedron Lett., 2014, 55, 224–226. https://doi.org/10.1016/j.tetlet.2013.11.001

16. B. Janardhan, B. Rajitha*, Peter A. Crooks. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient heterogeneous catalyst for the one-pot synthesis of polyhydroquinolines via unsymmetrical Hantzsch reaction in aqueous medium. J. Saudi Chem. Soc., 2014, 18, 722–727. https://doi.org/10.1016/j.jscs.2014.01.009 

17. Janardhan Banothu, Krishnaiah Vaarla, Rajitha Bavantula*, Peter A. Crooks. Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature. Chin. Chem. Lett., 2014, 25, 172-175. https://doi.org/10.1016/j.cclet.2013.10.001

18. Ravibabu Velpula, Janardhan Banothu, Acharya Nagarjun Pyde, Rajitha Bavantula*. Synthesis of thioalkylated-4-aryltetrahydroquinazolinone derivatives and their antibacterial activity. Org. Commun., 2014, 7, 45-52. shorturl.at/suCES

19. Janardhan Banothu, Ravibabu Velpula, Rajitha Gali, Rajitha Bavantula*, Peter A. Crooks. Highly efficient conversion of fused 2-amino-4-aryl-4H-chromene-3-carbonitriles into fused 2-oxo-4-aryl-2H-chromene-3-carbonitriles using Vilsmeier conditions. Tetrahedron Lett., 2013, 54, 3862–3864. https://doi.org/10.1016/j.tetlet.2013.05.030

20. B. Janardhan, S. Vijayalaxmi, B. Rajitha*. Sulfamic acid-catalyzed multicomponent one-pot synthesis of polysubstituted pyridines and their antimicrobial activity. J. Heterocycl. Chem., 2013, 50, 1230-1235. https://doi.org/10.1002/jhet.1564

21. Janardhan Banothu, Rajitha Gali, Ravibabu Velpula, Rajitha Bavantula*. Brønsted acidic ionic liquid catalysis: An efficient and eco-friendly synthesis of novel fused pyranopyrimidinones and their antimicrobial activity. J. Chem. Sci., 2013, 125, 843-849. https://doi.org/10.1007/s12039-013-0459-x

22. Janardhan Banothu, Rajitha Bavantula*, Peter A. Crooks. Poly(4-vinylpyridinium) hydrogen sulfate catalyzed an efficient and eco-friendly protocol for the one-pot multicomponent synthesis of 1,8-acridinediones in aqueous medium. J. Chem., 2013, Article ID 850254, 6 pages. https://doi.org/10.1155/2013/850254

23. B. Janardhan, B. Rajitha,* Peter A. Crooks. Facile one-pot multicomponent synthesis of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylpyridine-3-carbonitriles using Brønsted acidic ionic liquid as catalyst under solvent-free conditions. Iranian J. Catal., 2013, 3, 41-47. shorturl.at/oAHQ9

24. Janardhan Banothu, Rajitha Bavanthula*. Brønsted acidic ionic liquid catalyzed highly efficient synthesis of chromeno-pyrimidinone derivatives and their antimicrobial activity. Chin. Chem. Lett., 2012, 23, 1015-1018. https://doi.org/10.1016/j.cclet.2012.06.041

25. Kuarm, B. Suresh., Janardan, B., Crooks, Peter A., Rajitha, B*. Xanthan sulfuric acid: An efficient bio-supported and recyclable solid acid catalyst for the synthesis of 2-aryl thiadiazolobenzimidazoles. Chin. J. Chem., 2012, 30, 947-950. https://doi.org/10.1002/cjoc.201100137

26. S. VijayaLaxmi, B. Janardhan, B. Rajitha*, P. Raghavaiah, Prathima Srinivas. Synthesis, single crystal X-ray studies and antimicrobial activities of novel indole barbiturates. Med. Chem. Res., 2012, 21, 2896-2901. https://doi.org/10.1007/s00044-011-9827-6

27. Banothu Janardhan, Somarapu VijayaLaxmi, Bavanthu Rajitha*. One-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: Improved protocol conditions for the Biginelli-like scaffolds. Heterocycl. Commun., 2012, 18, 93-97. https://doi.org/10.1515/hc-2011-0109

28. B. Janardhan, V. Ravibabu, Peter. A. Crooks, B. Rajitha*. L-proline catalyzed an efficient multicomponent one-pot synthesis of poly substituted pyridines. Org. Commun., 2012, 5, 186-195. https://www.acgpubs.org/doc/2020070912073422-OC-1205-262.pdf.

Visit Webpage

• Synthesis of Heterocyclic Compounds and Their Biological Applications

• Design and Development of Heterocyclic Small Molecules as Toll-Like Receptor(TLR) Agonists 

• Multicomponent Reactions 

• Methodology Development

• Green Chemistry

• Medicinal Chemistry

1. Sunil A. David, Janardhan Banothu, Mallesh Beesu and Michael Brush. Therapeutic compounds and methods of use thereof, US11014921B2 United States. Application granted on 25/05/2021.

2. Sunil A. David, Janardhan Banothu, Michael Brush, Collin Gustafson and Kathryn Trautman. Therapeutic compounds and methods of use thereof, US11465998B2. Application granted on 11/10/2022.

3. Janardhan Banothu and Arya C. G. A Regioselective Synthesis of 1,2-Disubstituted Benzimidazole. Indian Patent, Patent No.: 461737, Application No.: 202341012231, Filing Date: 22/02/2023, Grant Date: 25/10/2023.

4. Janardhan Banothu and Arya C. G. A Regioselective Synthesis of 2-Substituted Benzimidazole. Indian Patent, Patent No.: 500236, Application No.: 202341012233, Filing Date: 22/02/2023, Grant Date: 17/01/2024

5. Janardhan Banothu, Neethu Marian Thomas. 6-Fluoro-4-hydroxy-2-oxo-1,2- dihydroquinoline-3- carboxamide Derivatives as Chemotherapeutic Agents and Synthetic Method Thereof. Indian Patent, Patent No.: 557540, Application No.: 202341074688, Date of Filing: 02/11/2023, Grant Date: 07/01/2025.

1. NIT Calicut Faculty Research Seed Grant (2019-2022): Novel Fused Imidazole – Coumarin Hybrids: Synthesis, Characterization, Antimicrobial Investigation and Structural – Activity Relationship Studies (Fine Name: FRG/2019/CHEM/11). Amount: Rs. 5,00,000/- Completed.

2. ​DST-SERB Sponsored Project (2021-2024): Human Toll-Like Receptor 2-Selective Agonists: Design, Synthesis and Structure-Activity Relationship in Diverse Heterocyclic Scaffolds (File Name: EEQ/2020/000303). Amount: Rs. 47,34,700/- Completed.

3. NIT Calicut Student Innovative Project (2022-2023): Benzimidazole-Thiophene hybrids: Synthesis, Characterization and Evaluation of Human Multi Toll-Like Receptor (TLR) Agonistic Activity (File Name: CIEI/Student Innovations/2022-5). Amount: Rs. 90,000/- Completed.

4. I-STEM Catalyticgrant (2022-2023): Human Dual Toll-like Receptor (TLR) 2/8 Agonists: Design, Synthesis, Characterization and Structure-Activity Relationship Studies (Fine Name: I-STEM/Catalyticgrant/acad_23/2022-23).  Amount: Rs. 30,000/- Completed.

5. NIT Calicut Student Innovative Project (2023-2024): Development of Coumarin-thiazole Hybrids as Promising Anticancer Agents Against Breast, Colorectal, and Lung Cancers. NITC-PG Innovation (File Name: CIEI/SIP/2023-24/01). Amount: Rs. 75,000/- Completed

6. NIT Calicut Student Innovative Project (2024-2025): Identification of a Human Toll-Like Receptor (TLR) 2 Specific Agonists in Fused Thiophene Derivatives. NITC-PG Innovation (File Name: CIEI/Student Innovations/2024-1). Amount: Rs. 85,000/- Completed

7. Department of Science and Technology, WISE Fellowship for Ph.D. (WISE-PhD, 2026-2029): Human Toll-Like Receptor 2-Selective Agonists: Design, Synthesis, and Identification of Heterocyclic Small Molecules as Potential Vaccine Adjuvants (File No.: DST/WISE-PhD/CS/2024/129 (TPN: 111062), Dated: 25/03/2026). Amount: Rs. 20,48,400/- (Including Research Grant of Rs. 1,50,000/-). Ongoing.

8. Anusandhan National Research Foundation (ANRF, 2026-2029): Exploring the Potential of Human Dual- and Multi-Toll-Like Receptor Agonists as Next-Generation Vaccine Adjuvants (File No.: ANRF/IRG/2025/000999/CS). Amount: Rs. 71,42,400/- Ongoing.

Theory Courses​

• S1 M.Sc. Chemistry: CY6302D - Concepts of Organic Chemistry and Introductory Biochemistry

• S1 M.Sc. Chemistry: CY6302E - Basic Concepts of Organic Chemistry 

• S2 M.Sc. Chemistry: CY6312D/CY6312E - Chemistry of Multiple Bonds and Rearrangement Reactions 

• S3 M.Sc. Chemistry: CY7302D - Synthetic Methodologies in Organic Chemistry                      

• S4 M.Sc. Chemistry (Elective): CY7363D - Heterocyclic Chemistry

• S4 M.Sc. Chemistry (Elective): CY7353D - Medicinal Chemistry                                              

• S1/S2 B.Tech.: CY1001D - Chemistry

• S2 B.Tech, Department of Bioscience and Engineering: CY1003E - General Chemistry 

• S4 B.Tech. Chemical Engineering: CY2002D - Organic Chemistry

• S2 B.Sc.-B.Ed.: ED1111E - Basic Concepts in Organic Chemistry and Stereochemistry

• S5 B.Sc.-B.Ed.: ED3102E - Natural Products, Heterocycles and Spectroscopic Methods of Characterization  

Laboratory Courses​

• S1/S2 B.Tech.: CY1094D - Chemistry Laboratory

• S3. B.Sc.-B.Ed.: ED2103E - Organic Chemistry Laboratory   

PhD Students

Ongoing:

1. Mr. Praveen Telukuntla (Reg. No.: P210005CY)

2. Ms. Neethu Mariam Thomas (Reg. No.: P210109CY)

3. Ms. Punya V P (Reg. No.: P220088CY)

4. Ms. Amrutha P G (Reg. No.: P220088CY)

5. Ms. Oshin Daisy E B (Reg. No.: P240226CY)

Awarded:

1. Dr. Arya C G (Reg. No.: P180052CY)

   Thesis Title: Synthesis, Anticancer and Antibacterial Evaluation of Novel Benzimidazole Derivatives

   Date of registration: 19/07/2018; Date of award/defense: 30/08/2024

2. Dr. Fabitha K (Reg. No.: P190118CY)

   Thesis Title: Synthesis and Identification of Novel Chromene and Pyrazole Derivatives as Potential Anticancer Agents

   Date of Registration: 14/12/2019; Date of award/defense: 11/04/2025

3. Dr. Munugala Chandrakanth (Reg. No.: P210004CY)

   Thesis Title: Design, Synthesis, and Biological Evaluation of Diverse Heterocyclic Scaffolds as Potential Human Toll-Like Receptor Agonists and Therapeutic Agents.

   Date of Registration: 18/08/2021; Date of award/defense: 07/04/2026

PG Dissertations:

Ongoing:

1. Fathima C O (Reg. No.: 242770075, KUHS)

2. Aleemath Sa Adiya K (Reg. No.: M251137CY, NITC)

3. Arathi. C. C (Reg. No.: M251144CY, NITC)

4. Niranjana J (Reg. No.: M250440CY, NITC)

5. Anju C (Reg. No.: 25CHMS16, HCU) 

6. Aswathy Nandh N N (Reg. No.: 25CHMS34, HCU)

7. Archana S Kumar (Reg. No.: 2025CHM003, IIEST Shibpur)

8. Fathima T T (Reg. No.: 22021624, CUSAT)

9. Feba John (Reg. No.: 20241076, IISER Tirupati)

10. Silvia Kannukadan Mycle (Reg. No.: CCAZSCH040, Christ College, Irinjalakuda)

Awarded:

1. Shabana Sherin Vadakethil (Reg. No. 012325, MG University): Title: Synthesis and Characterization of 1,3,4,5-Tetrasubstituted Pyrazole-Acrylonitrile Derivatives. Duration: January – June 2025 

2. Tharun E M (Reg. No.: M241262CY, NIT Calicut, Minor Project): Title: Pyrimidine Derivatives: Anticancer Activity and Mechanism of Action. Duration: January – April 2025.

3. Fathima Misri (Reg. No.: M241215CY, NIT Calicut, Minor Project): Title: Heterocyclic Small Molecules as Potential Antiviral Agents Against Enterovirus. Duration: January – April 2025

4. Gopika Nair (Reg. No.: M241218CY, NIT Calicut, Minor Project): Title: Pyrimidines Derivatives as Potential Anti-HIV Agents. Duration: January – April 2025.

5. Ambika M (Reg. No.: M230286CY, NIT Calicut, Project Phase-II): Title: Quinoline-3-carboxamide Derivatives: Synthesis, Characterization, Molecular Docking and ADMET Predictions. Duration: January – April 2025.

6. Sivapriya M S (Reg. No.: M231029CY, NIT Calicut, Project Phase-II): Title: Coumarin – 1,2,3-Triazole – Thiazole Hybrids: Design, Synthesis, Characterization and Anticancer Activity. Duration: January – April 2025. 

7. Ambika M (Reg. No.: M230286CY, NIT Calicut, Project Phase-I): Title: Quinolone-3-carboxamide Derivatives: Synthesis and Identification of Potential Anticancer Agents Through SAR Studies. Duration: July – December 2024.

8. Sivapriya M S (Reg. No.: M231029CY, NIT Calicut, Project Phase-I): Title: Design, Synthesis, Characterization and Anticancer Activity of Coumarin – 1,2,3-Triazole – Thiazole Hybrids. Duration: August – December 2024.

9. Ambika M (Reg. No.: M230286CY, NIT Calicut, Minor Project): Title: Recent Developments on Synthesis and Anticancer Activity of Coumarin – 1,3,4-Thiadiazole Hybrids. Duration: January – May 2024.

10. Sivapriya M S (Reg. No.: M231029CY, NIT Calicut, Minor Project): Title: Comprehensive Review on Synthesis and Anti-Tubercular Activity of Coumarin – 1,2,3-Triazole Hybrids. Duration: January – May 2024. 

11. Nithin Kumar S (Reg. No.: M230797CY, NIT Calicut): Title: A Comprehensive Review on Synthesis of Coumarin-Oxazole Derivatives and their Antimicrobial Activity. Duration: January – May 2024.

12. Fathima Thirikkottu (Reg. No.: KVAWMPC006, MES KEVEEYAM, Calicut University): Title: Synthesis and Characterization of Thioacetamide – Linked Benzimidazole – Thiazole Hybrids. Duration: March – May 2024

13. Shashwat Subhankar Khuntia (Reg. No.: M220581CY, NIT Calicut): Title: Novel Thiazoles Derivatives as Potential Human Toll-Like Receptor 2/8 Agonists: Design, Synthesis, Characterization and In Silico Studies.  Duration: January – May 2024.

14. Manas Kumar Barik (Reg. No.: M220574CY, NIT Calicut): Title: Design, Synthesis and In Silico Studies of Novel Coumarin-3-Carboxamide Derivatives. Duration: January – May 2024.

15. Alaka Vinod (Reg. No.: M220572CY, NIT Calicut): Title: Design, Synthesis, and Characterization of Novel Thiazole Derivatives with In Silico ADMET Predictions and Molecular Docking Studies. Duration: January – April 2024.

16. Demina T D (Reg. No.: 2247440, Christ University Bangalore): Title: Synthesis, Characterization and Photophysical Properties of Novel 5-Amino-3-substituted-1H-pyrazole-4-carbonitriles. Duration: May – July 2023.

17. Sharif Aslam C P (M210716CY, NIT Calicut): Title: Benzimidazole – Thiazole Hybrids: Design, Synthesis Characterization and In Silico Molecular Docking Studies, and ADMET Predictions. Duration: January – April 2023.

18. Paritosh Dey (M210290CY, NIT Calicut): Title: Benzimidazole – Fused Thiophene Hybrids: Synthesis, Characterization, and Evaluation of Human Toll-Like Receptor-2/8 Agonistic Activity, and ADMET Predictions. Duration: January – April 2023.

19. Manju G Nair (Reg. No.: SMAUMCH010, St. Marys College, Calicut University): Title: Synthetic Strategies of Coumarin – 1,3,4-Oxadiazole hybrids. Duration: January – June 2022.

20. Mujmina K (Reg. No.: SMAUMCH011, St. Marys College, Calicut University): Title: Methods for the Synthesis of Chromene Derivatives. Duration: January – June 2022.

21. Raheema Thasneem (Reg. No.: SMAUMCH012, St. Marys College, Calicut University): Title: A Comprehensive Review on Thiophene and Benzimidazole Hybrids. Duration: January – June 2022.

22. Simple T R (Reg. No.: SMAUMCH014, St. Mary's College, Calicut University): Title: A review on synthesis and biological applications of quinoline-carboxamide derivatives. Duration: January – June 2022.

23. Hiba Haneefa Panayan Thodika (KAHM Unity Women’s College, Calicut University): Title: Novel Chromene Derivatives: Design, Synthesis, Characterization and in silico Molecular Docking Studies, and ADMET Predictions. Duration: April - July 2022.

24. Manivarna Nair (M200639CY, NIT Calicut): Title: Specific - hTLR2 and Dual - hTLR2/8 Agonists: Design, Synthesis, Characterization and in silico Molecular Docking Studies, and ADMET Predictions. Duration: January 2022 - May 2022. 

25. Akash Behera (M200652CY, NIT Calicut): Title: Benzimidazole - Acrylonitriles: Design, Synthesis, Characterization and in silico Molecular Docking Studies, and ADMET Predictions. Duration: January 2022 - May 2022.

26. Rakendu N Pramod (Reg. No.: 191611, IIRBS, MG University, Kottayam): Title: Design, Synthesis and Biological Evaluation of Novel Heterocyclic Embedded Amide and Thioamide Linked Derivatives as Potent Inhibitors of 
    Mycobacterium Tuberculosis. Duration: April – September 2021.

27. Catherine Healthina Pasangha (Reg. No.: M190678CY, NIT Calicut): Title: Human Toll Like Receptor-2 Agonist: Design, Synthesis, In Silico ADMET and Molecular Docking Studies of Quinoline-3-Carboxamides. Duration: January – May 2021.

28. Subhasree Barik (Reg. No.: M180495CY, NIT Calicut): Title: Development of a Novel Method for the Synthesis of Numerous Benzimidazole Derivatives. Duration: December 2019 – July 2020. 

29. D. Raj Kishore (Reg. No.: M180509CY, NIT Calicut): Title: Synthesis and Characterization of Novel 3,4,5-Trisubstituted Pyrazole Derivatives. Duration: December 2019 – July 2020.

30. Drisya Ajith (Reg. No.: AM.SC.P2CHM18005, Amrita Vishwa Vidyapeetham): Title: Synthesis and Characterization of Novel 3-(1-methyl-1H-benzo[d]imidazol-2-yl)-2H-chromen-2-one derivatives. Duration: December 2019 – March 2020.

31. Hamdah Tharayil (Farook College, Calicut University): Title: Synthesis and Characterization of Novel N-(1H-benzo[d]imidazol-2-yl)-2-oxo-2H-chromene-3-carboxamide derivatives. Duration: April – June 2019.

32. Lakshmi K J (Reg. No.: RSASMCH006, Calicut University): Title: Synthesis and Characterization of Coumarin Embedded Novel Benzimidazole Derivatives. Duration: April – May 2019.
    

33. Jumana A P (PSMO College, Tirurangadi, Calicut University): Title: Synthesis and characterization of novel 3-(1-substituted-1H-benzo[d]imidazol-2-yl)-2H-chromen-2-one derivatives. Duration: March – June 2019.
    

34. Bommanaboina Basavaiah (Reg. No.: M170559CY, NIT Calicut): Title: Synthesis, characterization, antibacterial evaluation and molecular docking studies of novel chalcone-triazole-morpholine hybrids. Duration: December 2018 – May 2019.

UG/PG Interns 

1. Tharun E M (Reg. No.: M241262CY, NIT Calicut): Title: Synthesis and in vitro Anticancer Evaluation of Novel Fused 3,4-dihydropyrimidin-2(1H)-ones and Thiones. Duration: May – July 2025

2. Swaliha Lizar (Reg. No.: M241260CY, NIT Calicut): Title: Synthesis and Anticancer Evaluation of Novel Pyrazole-Embedded Fused 3,4-dihydropyrimidin-2(1H)-ones and Thiones. Duration: May – July 2025

3. Neenu Elizabeth Mathew (Reg. No.: SIP414, IISER Tirupati): Title: Sodium Fluoride Catalyzed Highly Efficient Synthesis of 2,4-Disubsituted Thiazole Derivatives.  Duration: May – June 2025

4. Vaishnavi (Reg. No.: SIP153, IIT Palakkad): Title: Synthesis and Characterization of Pyrazole-Acrylonitrile Derivatives. Duration: May – June 2025.

5. Naseeba Parween PT (Reg. No.: SIP002, IIT Palakkad): Title: Synthesis and Characterization of Thiazole and Pyrazole Derivatives. Duration: May – June 2025.

6. Ambika M (Reg. No.: M230286CY, NIT Calicut): Title: Synthesis, Characterization and Anticancer Evaluation of Coumarin – 1,3,4-Thiadiazole Hybrids. Duration: May – July 2024.

7. Sivapriya M S (Reg. No.: M231029CY, NIT Calicut): Title: Coumarin – 1,2,3-Triazole Hybrids: Design, Synthesis, Characterization and Anticancer Activity. Duration: May – July 2024.

8. Anupriya A K (Reg. No. 23CHP006, Karpagam Academy of Higher Education): Title: Synthesis, Characterization, and Anticancer Evaluation of Novel Quinoline-3-carboxamide Derivatives. Duration: June – August 2024.

9. Bhavya P (Reg No.: 2201105009, Central University of Kerala): Title: Diverse Synthetic Strategies of Coumarin-1,3,4-Oxadiazole Hybrids. Duration: May – June 2023.

10. Anika (Kirori Mal College, University of Delhi): Title: Design and Synthesis of Macrocyclic Toll-Like Receptor (TLR)-2 Agonists. Duration: June – July 2021

11. Ankana Sengupta (Krishnath College, West Bengal): Title: Small Molecule Toll-Like Receptor (TLR) Agonists: Design and Synthesis. Duration: June – July 2021.

12. Nayk Tanya Jayaprakash (Guru Nanak College of Arts, Science and Commerce, Mumbai): Title: Coumarin-Thiazole Hybrid Molecules: Synthesis and Biological Applications. Duration: June – July 2021.

1. Ph.D's: Highly motivated and interested students wanted to work in the field of Organic Chemistry/Heterocyclic Chemistry/Medicinal Chemistry can apply through the NITC Ph.D. program and contact me through janardhan@nitc.ac.in/+91-8111938615

2. Post.Doc.: Interested candidates with postdoctoral research fellowships from any funding agency can directly contact me via email or a phone call

3. Master's Thesis and Internships: Interested students can directly contact me via email or phone call

1. European Journal of Medicinal Chemistry 303 (2026) 118435. https://doi.org/10.1016/j.ejmech.2025.118435

2. Bioorganic & Medicinal Chemistry Letters 131 (2026) 130444. https://doi.org/10.1016/j.bmcl.2025.130444  

3. Bioorganic & Medicinal Chemistry 130 (2025) 118352. https://doi.org/10.1016/j.bmc.2025.118352

4. Journal of Molecular Structure 1333 (2025) 141693. https://doi.org/10.1016/j.molstruc.2025.141693

5. Bioorganic & Medicinal Chemistry Letters, 2024, 110, 129881. https://doi.org/10.1016/j.bmcl.2024.129881. 

6. New Journal of Chemistry, 2024, 48, 8038–8054 . https://doi.org/10.1039/D4NJ00824C.