Publications From NITC

1. Arya C G, Munugala Chandrakanth, Fabitha K, Neethu Mariam Thomas, Rakendu N Pramod, Ramesh Gondru* and Janardhan Banothua.* Coumarin - Benzimidazole Hybrids: A Review on Diverse Synthetic Strategies. Results in Chemistry, 2022, 4, 100631. https://doi.org/10.1016/j.rechem.2022.100631.

2. Fabitha K, Arya C G, Munugala Chandrakanth and Janardhan Banothu.* Green Chemistry Approach: Sodium Fluoride-Catalysed Highly Efficient Microwave Irradiation-Assisted Synthesis of Substituted Chromene Derivatives in Aqueous Medium. Research on Chemical Intermediates (2022). https://doi.org/10.1007/s11164-022-04929-w

3. Fabitha K, Arya C G, Shyam Perugu, Ramesh Gondru, Janardhan Banothu*. 1,2,3-Triazole linked Chalcone-Morpholine hybrids: Synthesis, in vitro Antibacterial Evaluation and in silico ADMET Predictions. Polycycl. Aromat. Compd (2022). https://doi.org/10.1080/10406638.2022.2130369 

4. K. Fabitha, Munugala Chandrakanth, Rakendu N. Pramod, C. G. Arya, Yupeng Li and Janardhan Banothu.* Recent Developments in the Synthesis of Indole-Pyrazole Hybrids. ChemistrySelect, 2022, 7, e202201064. https://doi.org/10.1002/slct.202201064 

5. Arya C G, Ramesh Gondru, Yupeng Li* and Janardhan Banothua*. Coumarin–Benzimidazole Hybrids: A Review of Developments in Medicinal Chemistry. Eur. J. Med. Chem., 2022, 227, 113921. https://doi.org/10.1016/j.ejmech.2021.113921

6. Ramesh Gondru, Sirisha Kanugala, Sneha Raj, C Ganesh Kumar, Mukesh Pasupuleti, Janardhan Banothu, Rajith Bavantula*. 1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. Bioorganic Med. Chem. Lett., 2021, 33,  127746. https://doi.org/10.1016/j.bmcl.2020.127746

7. Rajitha Deshineni, Arya C G, Janardhan Banothu*, Ravibabu Velpula and Gyanakumari Chellamella*. Synthesis, anticancer and antibacterial evaluation of novel 1,3-disubstituted-1H-pyrazole-4-yl-methylene embedded fused thiazolo[2,3-b]quinazolinones. Chem. Data Collect., 2020, 30, 100546. https://doi.org/10.1016/j.cdc.2020.100546

8. G. Rajitha, C. G. Arya, B. Janardhan*, S. V. Laxmi, G. Ramesh and U. Sujana Kumari. 3-Aryl/heteryl-5-phenylindeno[1,2-d]thiazolo[3,2-a]pyrimidin-6(5H)-ones: Synthesis, characterization and antimicrobial investigation. Russ. J. Bioorganic Chem., 2020, 46(4), 612-619. https://doi.org/10.1134/S106816202004007X

Publications from Ph.D. and Post-Doc.

1. Ziwei Hu, Janardhan Banothu, Mallesh Beesu, Collin J. Gustafson, Michael J. H. Brush, Kathryn L. Trautman, Alex C. D. Salyer, Balaji Pathakumari, and Sunil A. David*. Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides. ACS Med. Chem. Lett., 2019, 10, 132−136. (First three authors have equal contributions). https://doi.org/10.1021/acsmedchemlett.8b00540 

2. Janardhan Banothu, Rajitha Gali, Ravibabu Velpula, Rajitha Bavantula*. Brønsted acidic ionic liquid catalyzed an efficient and eco-friendly protocol for the synthesis of 2,4,5-trisubstituted-1H-imidazoles under solvent-free conditions. Arab. J. Chem., 2017, 10, S2754–S2761. https://doi.org/10.1016/j.arabjc.2013.10.022 

3. B. Janardhan, B. Rajitha*, Peter A. Crooks. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient and recyclable Bronsted acid catalyst for the synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones. J. Saudi Chem. Soc., 2016, 20, S221–S226. https://doi.org/10.1016/j.jscs.2012.10.007

4. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Rajitha Bavantula*. Synthesis of novel fused thiazolo[3,2-a]pyrimidin-3-ols and evaluation for their antibacterial activity. J. Heterocycl. Chem., 2016, 53, 51-55. https://doi.org/10.1002/jhet.2281

5. Ramesh Gondru, Janardhan Banothu, Ranjith Kumar Thatipamula, Althaf Hussain SK, Rajitha Bavantula*. 3-(1-Phenyl-4-((2-(4-arylthiazol-2-yl)hydrazono)-methyl)-1H-pyrazol-3-yl)-2H-chromen-2-ones: one-pot three component condensation, in vitro antimicrobial, antioxidant and molecular docking studies. RSC Adv., 2015, 5, 33562-33569. https://doi.org/10.1039/C5RA04196A 

6. Rajitha Gali, Janardhan Banothu, Ramesh Gondru, Rajitha Bavantula*, Yashodhara Velivela, Peter A. Crooks. One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies. Bioorg. Med. Chem. Lett., 2015, 25, 106–112. https://doi.org/10.1016/j.bmcl.2014.10.100 

7. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Rajitha Deshineni, Rajitha Bavantula*. 1-Sulfopyridinium chloride: Green and expeditious ionic liquid for the one-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones under solvent free conditions. Chin. Chem. Lett., 2015, 26, 309–312. https://doi.org/10.1016/j.cclet.2014.11.030

8. Janardhan Banothu, Srinivas Basavoju, Rajitha Bavantula*. Pyridinium ylide assisted highly stereoselective one-pot synthesis of trans-2-(4-chlorobenzoyl)-3-aryl-spiro [cyclopropane-1,2′-inden]-1′,3′-diones and their antimicrobial and nematicidal activities. J. Heterocycl. Chem., 2015, 52, 853-860. https://doi.org/10.1002/jhet.2059

9. Rajitha Gali, Janardhan Banothu, Rajitha Bavantula*. One-pot multicomponent synthesis of novel substituted imidazo[1,2-a]pyridine incorporated thiazolylcoumarins and their antimicrobial activity. J. Heterocycl. Chem., 2015, 52, 641-646. https://doi.org/10.1002/jhet.2116 

10. Gondru Ramesh, Banothu Janardhan, Bavantula Rajitha*. Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation. Res. Chem. Intermed., 2015, 41, 8099–8109. https://doi.org/10.1007/s11164-014-1879-z

11. Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Yakaiah Sargam, Rajitha Bavantula*. One pot and solvent-free synthesis of 3-(9-hydroxy-3-methoxy-7-aryl-6,7,9,10-tetrahydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9-yl)-2H-chromen-2-ones and their antibacterial evaluation. Turk. J. Chem., 2015, 39, 620 – 629. https://doi.org/10.3906/kim-1410-64

12. Janardhan Banothu, Manjulatha Khanapur, Srinivas Basavoju, Rajitha Bavantula*, Muralikrishna Narra, Sadanandam Abbagani. Synthesis, characterization and biological evaluation of fused thiazolo[3,2-a]pyrimidine derivatives. RSC Adv., 2014, 4, 22866-22874. https://doi.org/10.1039/C4RA02514H

13. Rajitha Gali, Janardhan Banothu, Mahendar Porika, Ravibabu Velpula, Rajitha Bavantula* Sadanandam Abbagani. Synthesis and in vitro cytotoxic activity of novel coumarinylimidazo[2,1-b]thiazole derivatives. RSC Adv., 2014, 4, 53812-53819. https://doi.org/10.1039/C4RA11428K

14. Rajitha Gali, Janardhan Banothu, Mahendar Porika, Ravibabu Velpula, Sairengpuii Hnamte, Rajitha Bavantula*, Sadanandam Abbagani, Siddhardha Busi. Indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones: Synthesis, characterization and evaluation of anticancer and antimicrobial activities. Bioorg. Med. Chem. Lett., 2014, 24, 4239–4242. https://doi.org/10.1016/j.bmcl.2014.07.030

15. Janardhan Banothu, Srinivas Basavoju, Rajitha Bavantula*, Peter A. Crooks. Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks. Tetrahedron Lett., 2014, 55, 224–226. https://doi.org/10.1016/j.tetlet.2013.11.001

16. B. Janardhan, B. Rajitha*, Peter A. Crooks. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient heterogeneous catalyst for the one-pot synthesis of polyhydroquinolines via unsymmetrical Hantzsch reaction in aqueous medium. J. Saudi Chem. Soc., 2014, 18, 722–727. https://doi.org/10.1016/j.jscs.2014.01.009 

17. Janardhan Banothu, Krishnaiah Vaarla, Rajitha Bavantula*, Peter A. Crooks. Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature. Chin. Chem. Lett., 2014, 25, 172-175. https://doi.org/10.1016/j.cclet.2013.10.001

18. Ravibabu Velpula, Janardhan Banothu, Acharya Nagarjun Pyde, Rajitha Bavantula*. Synthesis of thioalkylated-4-aryltetrahydroquinazolinone derivatives and their antibacterial activity. Org. Commun., 2014, 7, 45-52. shorturl.at/suCES

19. Janardhan Banothu, Ravibabu Velpula, Rajitha Gali, Rajitha Bavantula*, Peter A. Crooks. Highly efficient conversion of fused 2-amino-4-aryl-4H-chromene-3-carbonitriles into fused 2-oxo-4-aryl-2H-chromene-3-carbonitriles using Vilsmeier conditions. Tetrahedron Lett., 2013, 54, 3862–3864. https://doi.org/10.1016/j.tetlet.2013.05.030

20. B. Janardhan, S. Vijayalaxmi, B. Rajitha*. Sulfamic acid-catalyzed multicomponent one-pot synthesis of polysubstituted pyridines and their antimicrobial activity. J. Heterocycl. Chem., 2013, 50, 1230-1235. https://doi.org/10.1002/jhet.1564

21. Janardhan Banothu, Rajitha Gali, Ravibabu Velpula, Rajitha Bavantula*. Brønsted acidic ionic liquid catalysis: An efficient and eco-friendly synthesis of novel fused pyranopyrimidinones and their antimicrobial activity. J. Chem. Sci., 2013, 125, 843-849. https://doi.org/10.1007/s12039-013-0459-x

22. Janardhan Banothu, Rajitha Bavantula*, Peter A. Crooks. Poly(4-vinylpyridinium) hydrogen sulfate catalyzed an efficient and eco-friendly protocol for the one-pot multicomponent synthesis of 1,8-acridinediones in aqueous medium. J. Chem., 2013, Article ID 850254, 6 pages. https://doi.org/10.1155/2013/850254

23. B. Janardhan, B. Rajitha,* Peter A. Crooks. Facile one-pot multicomponent synthesis of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylpyridine-3-carbonitriles using Brønsted acidic ionic liquid as catalyst under solvent-free conditions. Iranian J. Catal., 2013, 3, 41-47. shorturl.at/oAHQ9

24. Janardhan Banothu, Rajitha Bavanthula*. Brønsted acidic ionic liquid catalyzed highly efficient synthesis of chromeno-pyrimidinone derivatives and their antimicrobial activity. Chin. Chem. Lett., 2012, 23, 1015-1018. https://doi.org/10.1016/j.cclet.2012.06.041

25. Kuarm, B. Suresh., Janardan, B., Crooks, Peter A., Rajitha, B*. Xanthan sulfuric acid: An efficient bio-supported and recyclable solid acid catalyst for the synthesis of 2-aryl thiadiazolobenzimidazoles. Chin. J. Chem., 2012, 30, 947-950. https://doi.org/10.1002/cjoc.201100137

26. S. VijayaLaxmi, B. Janardhan, B. Rajitha*, P. Raghavaiah, Prathima Srinivas. Synthesis, single crystal X-ray studies and antimicrobial activities of novel indole barbiturates. Med. Chem. Res., 2012, 21, 2896-2901. https://doi.org/10.1007/s00044-011-9827-6

27. Banothu Janardhan, Somarapu VijayaLaxmi, Bavanthu Rajitha*. One-pot synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: Improved protocol conditions for the Biginelli-like scaffolds. Heterocycl. Commun., 2012, 18, 93-97. https://doi.org/10.1515/hc-2011-0109

28. B. Janardhan, V. Ravibabu, Peter. A. Crooks, B. Rajitha*. L-proline catalyzed an efficient multicomponent one-pot synthesis of poly substituted pyridines. Org. Commun., 2012, 5, 186-195. shorturl.at/kHT38

Visit Webpage

• Synthesis of Heterocyclic Compounds and Their Biological Applications

• Design and Development of Heterocyclic Small Molecules as Toll-Like Receptor(TLR) Agonists 

• Multicomponent Reactions 

• Methodology Development

• Green Chemistry

• Medicinal Chemistry

1. Sunil A. David, Janardhan Banothu, Mallesh Beesu and Michael Brush. Therapeutic compounds and methods of use thereof, US11014921B2 United States. Application granted on 25/05/2021.

2. Sunil A. David, Janardhan Banothu, Michael Brush, Collin Gustafson and Kathryn Trautman. Therapeutic compounds and methods of use thereof, US11465998B2. Application granted on 11/10/2022.

1. ​DST-SERB Sponsored Project (2021-2024): Human Toll-Like Receptor 2-Selective Agonists: Design, Synthesis and Structure-Activity Relationship in Diverse Heterocyclic Scaffolds (File Name: EEQ/2020/000303). Amount: Rs. 47,34,700/- Ongoing.

2. NIT Calicut Student Innovative Project (2022-2023): Benzimidazole-Thiophene hybrids: Synthesis, Characterization and Evaluation of Human Multi Toll-Like Receptor (TLR) Agonistic Activity. Amount: Rs. 90,000/- Ongoing.

3. NIT Calicut Faculty Research Seed Grant (2019-2022): Novel Fused Imidazole – Coumarin Hybrids: Synthesis, Characterization, Antimicrobial Investigation and Structural – Activity Relationship Studies. Amount: Rs. 5,00,000/- Completed.

Theory Courses​

• S1 M.Sc. Chemistry: CY6302 - Concepts of Organic Chemistry and Introductory Biochemistry

• S2 M.Sc. Chemistry: CY6312 - Chemistry of Multiple Bonds and Rearrangement Reactions 

• S3 M.Sc. Chemistry: CY7302 - Synthetic Methodologies in Organic Chemistry                      

• S4 M.Sc. Chemistry (Elective): CY7363D - Heterocyclic Chemistry

• S4 M.Sc. Chemistry (elective): CY7353 - Medicinal Chemistry                                              

• S1/S2 B.Tech.: CY1001D - Chemistry                                                                           

• S4 B.Tech. Chemical Engineering: CY2002D - Organic Chemistry                                                                                                                                                                                                       

Laboratory Courses​

• S1/S2 B.Tech.: CY1094D - Chemistry Laboratory

Ph.D. Students

MSc. Project Students

PG Dissertations

1. Ms. Hiba Haneefa Panayan Thodika. Title: Synthesis of novel chromene derivatives. April 2022 - July 2022. KAHM Unity Women’s College, Manjeri, Malapuram.

2. Ms. Manivarna Nair. Title: Specific - hTLR2 and Dual - hTLR2/8 Agonists: Design, Synthesis, Characterization and in silico Molecular Docking Studies, and ADMET Predictions. January 2022 - May 2022. National Institute of Technology Calicut. 

3. Mr. Akash Behera. Benzimidazole - Acrylonitriles: Design, Synthesis, Characterization and in silico Molecular Docking Studies, and ADMET Predictions. January 2022 - May 2022. National Institute of Technology Calicut.  

4. Ms. Rakendu N Pramod. Title: Design, Synthesis and Biological Evaluation of Novel Heterocyclic Embedded Amide and Thioamide Linked Derivatives as Potent Inhibitors of Mycobacterium Tuberculosis. April 2021 - July 2021. Institute for Integrated Programmes and Research in Basic Sciences (IIRBS), MG University, Kottayam.

5. Ms. Catherine Healthina Pasangha. Title: Human Toll Like Receptor-2 Agonist: Design, Synthesis, In Silico ADMET and Molecular Docking Studies of Quinoline-3-Carboxamides. January 2021 – May 2021. National Institute of Technology Calicut.

6. Ms. Drisya Ajith. Title: Synthesis and Characterization of Novel 3-(1-methyl-1H-benzo[d]imidazol-2-yl)-2H-chromen-2-one derivatives. December 2019 – March 2020. Department of Chemistry, Amrita Vishwa Vidyapeetham, School of Arts and Sciences, Amritapuri.

7. Mr. D. Raj Kishore. Title: Synthesis and Characterization of Novel 3,4,5-Trisubstituted Pyrazole Derivatives. December 2019 – July 2020. National Institute of Technology Calicut.

8. Ms. Subhasree Barik. Title: Development of a Novel Method for the Synthesis of Numerous Benzimidazole Derivatives. December 2019 – July 2020. National Institute of Technology Calicut.

9. Ms. Lakshmi K J. Title: Synthesis and Characterization of Coumarin Embedded Novel Benzimidazole Derivatives. April 2019 – May 2019. Department of Chemistry, R. Sankar Memorial SNDP Yogam Arts & Science College, Koyilandi.

10. Ms. Hamdah Tharayil. Title: Synthesis and Characterization of Novel N-(1H-benzo[d]imidazol-2-yl)-2-oxo-2H-chromene-3-carboxamide derivatives. April 2019 – June 2019. Farook College, Calicut University.

11. Ms. Jumana A P. Title: Synthesis and characterization of novel 3-(1-substituted-1H-benzo[d]imidazol-2-yl)-2H-chromen-2-one derivatives. March 2019 – June 2019. Department of Chemistry, PSMO College, Tirurangadi, Calicut University.

12. Mr. Bommanaboina Basavaiah. Title: Synthesis, characterization, antibacterial evaluation and molecular docking studies of novel chalcone-triazole-morpholine hybrids. December 2018 – May 2019. National Institute of Technology Calicut.

​

Internship Students

1. Ms. Simple T R. Title: A Review on Synthesis and Biological Applications of Quinoline-Carboxamide Derivatives. September 2021 – December 2021. St. Marys College Sulthan Batheri Wayanad, Calicut University.

2. Ms. Raheema Thasneem. Title: A Comprehensive Review on Thiophene and Benzimidazole Hybrids. September 2021 – December 2021. St. Marys College Sulthan Batheri Wayanad, Calicut University.

3. Ms. Mujmina K. Title: Methpds for the synthesis of Chromene Derivatives. September 2021 – December 2021. St. Marys College Sulthan Batheri Wayanad, Calicut University.

4. Ms. Manju G Nair. Title: Synthetic Strategies of Coumrin-1,3,4-oxadiazole Hybrids. September 2021 – December 2021. St. Marys College Sulthan Batheri Wayanad, Calicut University.

5. Ms. Rakendu N Pramod. Title: Human Toll Like Receptor-2 Agonists: Synthesis and In Silico Molecular Docking Studies of Quinoline-3-Carboxamides. July 2021 – September 2021. Institute for Integrated Programmes and Research in Basic Sciences (IIRBS), MG University, Kottayam.

6. Ms. Nayk Tanya Jayaprakash. Title: Coumarin-Thiazole Hybrid Molecules: Synthesis and Biological Applications. June 2021 – July 2021. Guru Nanak College of Arts, Science and Commerce, Mumbai, Maharashtra.

7. Ms. Ankana Sengupta. Title: Small Molecule Toll-Like Receptor (TLR) Agonists: Design And Synthesis. June 2021 - July 2021. Krishnath College, West Bengal.

8. Ms. Anika. Title: Design and Synthesis of Macrocyclic Toll-Like Receptor (TLR)-2 Agonists. June 2021 - July 2021. Kirori Mal College, University of Delhi.

1. Post.Doc.: Interested candidates with Post-doctoral research fellowships from any funding agency can directly apply.​

2. Ph.D.'s: Highly motivated and Interested students in the field of organic chemistry, heterocyclic chemistry and Medicinal chemistry may apply through the NITC Ph.D. program.

3. Master Thesis and Internships: Interested students may contact janardhan@nitc.ac.in