Language Language Language
  • Clear Cache
    • DEPARTMENTS
    keyboard_arrow_left back to faculty list
    Dr. Tom Skaria
    Dr. Tom Skaria

    Assistant Professor

    Office Address:

    Room 304-2 , Bioscience and Engineering, National Institute of Technology (NIT) Calicut, NIT campus P O, Calicut-673601

    Contact no:

    04952285473

    Email ID:

    tomskaria@nitc.ac.in

    Home Address:

  • Dr. of Science , University of Zurich, Switzerland.

  • PhD course work in Immunology from ETH Zurich (Swiss Federal Institute of Technology), Switzerland

    • Educational Qualifications

    • Dr. of Science , University of Zurich, Switzerland.

    • PhD course work in Immunology from ETH Zurich (Swiss Federal Institute of Technology), Switzerland

    Journals

    Publications in SCI and PubMed indexed journals

    • Durga Geetha, B A Aysha Hameeda, Deepthi Jose, Nishamol Kuriakose, Tom Skaria. Novel Insights Into the Dynamic Conformational Transitions and Active Site Plasticity of Human Immunoregulatory Cathepsin S. Proteins. 2025.
    • Shahid Puthiyottil, Tom Skaria. Paracrine signaling mediators of vascular endothelial barrier dysfunction in sepsis: implications for therapeutic targeting. Tissue Barriers. 2025.
    • Durga Geetha, Tom Skaria. Cathepsin S: A key drug target and signalling hub in immune system diseases. International Immunopharmacology. 2025.
    • Shahid Puthiyottil, Deepthi Jose, Nishamol Kuriakose, Tom Skaria. The developmental and inflammatory disease target protein ADAM17 is vulnerable to off-target interaction by the drug eltrombopag: Insights from molecular modeling. Computers in Biology and Medicine. 2025.
    • Maneesha Kunnathattil, Pedapudi Rahul and Tom Skaria. Soluble vascular endothelial glycocalyx proteoglycans as potential therapeutic targets in inflammatory diseases. Immunology & Cell Biology. 2023. 
    • Ahsan Anjoom Sunil, Deepthi Jose, Sai Kumar Karri, Pukhraj Pukhraj, Jibin K Varughese, Tom Skaria. Biomolecular interactions between the antibacterial ceftolozane and the human inflammatory disease target ADAM17: a drug repurposing study. Journal of Biomolecular Structure and Dynamics. 2023.
    •  Ahsan Anjoom Sunil, Tom Skaria. Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing. Expert Opinion on Therapeutic Targets. 2022.
    • Tom Skaria, Johannes Vogel. The Neuropeptide a-Calcitonin Gene-Related Peptide as the Mediator of Beneficial Effects of Exercise in the Cardiovascular System. Frontiers in Physiology. 2022. 
    • Tom Skaria, Mostafa A Aboouf Ali, Johannes Vogel. Improved method for surgical induction of chronic hypertension in mice. Biology Open. 2022
    • Tom Skaria, Esther Bachli, Gabriele Schoedon. Transcriptional Regulation of Drug Metabolizing CYP Enzymes by Proinflammatory Wnt5A Signaling in Human Coronary Artery Endothelial Cells. Frontiers in Pharmacology, 2021; 12:619588.
    • Tom Skaria, Thomas Wälchli, Johannes Vogel. CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects. Trends in Molecular Medicine. 27, 7 -10, 2020.
    • Tom Skaria, Katharyn Mitchell, Olga Vogel, Thomas Walchli, Max Gassmann, Johannes Vogel. Blood pressure normalization-independent cardioprotective effects of endogenous, physical activity-induced alpha calcitonin gene-related peptide (CGRP) in chronic hypertension. Circulation Research. 125, 1124- 1140, 2019.
    • Tom Skaria, Esther Bachli, Gabriele Schoedon. Gene Ontology Analysis for Drug Targets of the Whole Genome Transcriptome of Human Vascular Endothelial Cells in Response to Proinflammatory IL-1. Front. Pharmacol. 2019; 10:414.
    • Tom Skaria, Esther Bachli, Gabriele Schoedon. RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1. Molecular Medicine. 2018:24:45.
    • Tom Skaria, Gabriele Schoedon. Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells. J Inflamm (Lond). 2017;14:15.
    • Tom Skaria, Esther Bachli, Gabriele Schoedon. WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells. J Inflamm (Lond). 2017;14:10.
    • Tom Skaria, Julia Burgener, Esther Bachli, Gabriele Schoedon. IL-4 causes hyperpermeability of vascular endothelial cells through Wnt5A signaling. 2016. PLoS ONE. 2016; 11:e0156002.
    • Tom Skaria, Esther Bachli, Gabriele Schoedon. Wnt5A/Ryk Signalling Critically Affects Barrier Function in Human Vascular Endothelial Cells. Cell Adh Migr. 2017 J;11(1):24-38.
    • René Günther Feichtinger, Daniel Neureiter, Tom Skaria, Silja Wessler, Timothy L Cover, Johannes Adalbert Mayr, Franz A Zimmermann, Gernot Posselt, Wolfgang Sperl, Barbara Kofler. Oxidative phosphorylation system in gastric carcinomas and gastritis. Oxidative Medicine and Cellular Longevity. 2017;1320241: 1- 15.

    Professional Experience

    • Post-Doctoral Scientist (full time) at Zurich Center for Integrative Human Physiology & Institute of Veterinary Physiology, University of Zürich, Switzerland, from 01/11/2015 till 31/03/2020

    • Scientific Collaborator at Inflammation Research Unit, Division of Internal Medicine, University Hospital of University of Zürich, Switzerland 16/05/2015 to date

    • Funding agency: SERB, India, Scheme: Start-up Research Grant (SRG) 2021

    Project title: Cathepsin-S as a novel direct drug target for preventing barrier and tissue destructive proinflammatory IL-1 beta signaling in primary, vascular endothelium: an in vitro study

    Granted amount: INR. 2962650/ (December 2021 to March 2024)

    • Scientific data from the publication Tom Skaria et al., PLoS ONE. 2016. was selected as the Biomedical Picture of the Day, 29 June 2016 by MRC London Institute of Medical Sciences, UK.

    • Scientific data from the publication Tom Skaria et al., Cell Adh Migr. 2017 was selected as the journal cover for Issue 1, volume 11, 2017 by Cell Adhesion and Migration, Taylor & Francis Group.

    • European Society of Cardiology Council on Basic Cardiovascular Science- ESC Congress 2019 Travel Award.

     

    • Laboratory Animal Science (rodents, conducted by University of Zurich and ETH Zurich, Switzerland, 2016).

    • Anatomy and Necropsy (rodents, conducted by University of Zurich and ETH Zurich, Switzerland, 2018).

    • Pain Recognition in Scientific Research Models (conducted by University of Zurich and ETH Zurich, Switzerland, 2019).

    Address:

    National Institute of Technology Calicut,
    NIT Campus P.O 673 601,
    Kozhikode, India.

    General

    Departments and Centres

    Committees / Cells

    Achievements

    Minutes & Reports

    Others

    Sponsored by NITCAA - Alumni of B.Tech 1993-97 Batch.
    Designed and Developed by Xpertconsortium Technologies LLP.
    Maintained by C-PRIME and CITRA, NITC.