1. R.M. Banik, A. Santhiagu, Extractive fermentation for enhanced gellan hydrolyzing enzyme production, World Journal of Microbiology and Biotechnology, 18, 715-720, 2002.

2. R. M. Banik, A. Santhiagu, B. Kanari, C. Sabarinath and S. N. Upadhyay, Technological Aspects of Extractive Fermentation Using Aqueous Two-phase Systems, World Journal of Microbiology and Biotechnology, 19, 337-348, 2003 .

3. R.M. Banik, A. Santhiagu, Improvement in production and quality of gellan gum by Sphingomonas paucimobilis under high dissolved oxygen tension levels, Biotechnology Letters, 28 (17), 1347-1350, 2006. 

4. R.M. Banik, A. Santhiagu, S.N. Upadhyay, Optimization of nutrients for gellan gum production by Sphingomonas paucimobilis ATCC-31461 in molasses based medium using response surface methodology, Bioresource Technology, 98 (4), 192-197, 2007.

5. A. Santhiagu, R.M. Banik, Optimization of gellan gum production by Sphingomonas paucimobilis with non-ionic surfactants using central composite design, Journal of Bioscience and Bioengineering, 105(3), 204-210, 2008.

6. A. Santhiagu, Nimalanandan. A., Sabitha.S., Indira Packialakhshmi, Agalya. S., Janani Priya, V., Enhanced production of laccase from Coriolos versicolor by nutrient optimization using response surface methodology, Applied Biochemistry and Biotechnology, 151(2-3):371-379, 2008.

7. Akash Marathakam, N. Kannappan, S. Jasemine, A. Santhiagu, M. Sreejith and M. Ajith, Studies on phytochemical and In-Vitro antioxidant potential of Justicia beddomei (Clarke) Bennett., Free radicals and antioxidants, 2(4), 2012, 26-31.

8.  P. Karthic, Shiny Joseph, Naveenji Arun, Lity Alen Varghese and A. Santhiagu, Biohydrogen production using anaerobic mixed bacteria: Process parameters optimization studies, Journal of Renewable and Sustainable Energy, 5, 2013, 063103.

9. M. Sreejith. N. Kannappan, A. Santhiagu, M. Akash M, P.M. Ajith and S. Jasemine, In vitro xanthine oxidase inhibitory and antioxidant activities of aerial parts of Flacourtia sepiaria, Oriental Pharmacy and Experimental Medicine, 13, 2013, 113-120.

10. M. Sreejith, N. Kannappan, A. Santhiagu ,  and P.M. Ajith, Phytochemical, Anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria, Asian Pacific Journal of Tropical Biomedicine, 3(12), 2013, 947-953 

11. S Jaya Prakash , A Santhiagu, S Jasemine , Preparation, Characterization and In Vitro Evaluation of Novel Gellan Gum-Raloxifene HCl Nanoparticles, J. Pharm. BioSci.,2, 2014,  263-71.

12. V. Harikrishnan, S. Madhusudhan and A. Santhiagu, Evaluation of novel, natural locust bean gum as sustained release and mucoadhesive component of tizanidine hydrochloride buccal tablets, Asian Journal of Pharmaceutical and Clinical Research, 8 (6), 2015, 7-10.

13. A Divya, A Santhiagu and S Jayaprakash, Cloning, expression and characterization of a highly active thermostable alkaline phosphatase from Bacillus licheniformis MTCC1483 in Escherichia coli BL21 (DE3), Applied Biochemistry and Microbiology, 52 (4), 2016, 358-365.

14. Ponniah Saravana Perumal, Stevin Wilson, and A. Santhiagu, Optimization of codon usage of the envelope protein E2 genefrom various genotypes of hepatitis C virus to predict the expression level in Pichia pastoris, Genes & Genomics, Doi:10.1007/s13258-016-0442-2

15. .  E. Nakkeeran, N. Saranya, M.S. Giri Nandagopal, A. Santhiagu and N. Selvaraju, Hexavalent chromium removal from aqueous solutions by a novel powder prepared from Colocasia esculenta leaves, International Journal of Phytoremediation, 18 (8), 2016, 812-821.

16. V. Harikrishnan, S. Madhusudhan and A. Santhiagu, Development and in Vitro Evaluation of Tizanidine hydrochloride Buccal Tablet using Tamarind Seed Gum, Journal of Pharmaceutical Sciences and Research, 8(3), 2016, 161-167.

17. Jilse Sebastian, C. Muraleedharan, and A. Santhiagu, A comparative study between chemical and enzymatic transesterification of high free fatty acid contained rubber seed oil for biodiesel production, Cogent Engg, 3 (1) 2016, 1-12.

18. Jilse Sebastian, Chandrasekharan Muraleedharan and Arockiasamy Santhiagu, Enzyme Catalysed Biodiesel Production from Rubber Seed Oil Containing High Free Fatty Acid, International Journal of Green Energy, 14 (8), 2017, 687-693.

19. K. R. Yuvaraja, A. Santhiagu and S. Jasemine, “Antioxidant and hepatoprotective potential of Hydnocarpus laurifolia: An in vitro and in vivo evaluation,” Journal of Pharmaceutical BioSciciences, vol. 6, no. 3, pp. 43-49. 2018.

20. A.B. Sathya, R. Sivashankar, V. Sivasubramanian, A. Santhiagu, Green algae as source for polyhydroxyalkanoate synthesis from food processing wastewater, Research Journal of Chemistry and Environment, 22, 66-74, 2018

21. Nisha S, Santhiagu A, Joji K, Process modeling and optimization of high yielding L-methioninase from a newly isolated Trichoderma harzianumusing response surface methodology and artificial neural network coupled genetic algorithm, Biocatalysis and Agricultural Biotechnology, 17, 2019, 299-308.

22. Adarsh VK and Santhiagu A, Identifying drug-like Inhibitors of Mycobacterium tuberculosis H37Rv SeryltRNASynthetase based on bioassay dataset: Homology modelling, docking and molecular dynamics simulation, Int.J. of Computational Biology and Drug Design (IJCBDD), 2019.

23. Manjusha CM,Santhiagu A, Soumiya S ,Adarsh VK and Jaya Prakash S, Phyre 2 and I-Tasser web portal for Protein modeling, Prediction and Validation of gel Q and gel K genes from gellan gum producing bacterial strain Sphingomonas paucimobilis ATCC 31461, Research J. Pharm. and Tech, 12(1), 2019, 27-36.

24.   Soumiya S, Santhiagu A, Manjusha CM, Adarsh VK andJaya Prakash S, Homology Modeling and Structural Validation of Gel C gene involved in the biosynthesis of Gellan from Sphingomonas paucimobilis ATCC 31461, Research J. Pharm. and Tech, 12(3), 2019, 1044-1050.

25.   K Joji, A Santhiagu, Nisha Salim, Computational Modeling of culture media for enhanced production of fibrinolytic enzyme from marine bacterium Fictibacilus sp. Strain SKA27 and in vitro evaluation of Fibrinolytic activity, 3Biotech, 9:323,2019.

26. K. R. Yuvaraja, A. Santhiagu and S. Jasemine and K.Gopalasatheeskumar, Hepatoprotecve activity of chloroform and ethyl acetate extract of Dipteracanthus patulus against paracetamol induced hepatotoxicity in ratsthrough anoxidant mechanism, Research Journal of Pharmacy and Technology, Vol. 13, no. 1, 2020.

1.  R.M. Banik, A. Santhiagu and J.K. Pandit, Extractive fermentation for enhanced production of gellanlyase by Bacillus amyloliquifaciens in aqueous two-phase systems, Procd. Indian Pharmaceutical Congress, 301, 2002.

2. R.M. Banik, A. Santhiagu Production of gellanlyase by Bacillus sp. using PEG – Potassium phosphate aqueous two-phase systems, Procd. Indian Chemical Engineering Congress, 35, 2002.

3. R. M. Banik, B. Kanari, A. Santhiagu and S. N. Upadhyay, Separation of Microbial Exopolysaccharide from Fermented Broth, Procd. Separation in Process Industries, 190-192, 2003.

4. R. M. Banik, M. Prakash, A. Anand and A. Santhiagu, Aqueous Two-phase System: A Biofriendly Method for Separation of Biochemicals, Procd. Separation in Process Industries, 181-189, 2003.

5. R.M. Banik, A. Santhiagu and J.K. Pandit, Effect of Non-ionic Surfactants on gellan Production by Sphingomonas paucimobilis, Procd. Indian Pharmaceutical Congress, 276, 2004.

6. R.M. Banik, A. Santhiagu, Effect of addition of rhamnose and additional nitrogen sources on the production on gellan by Sphingomonas paucimobilis, Procd. PTFD, 2005.

7. R.M. Banik, A. Santhiagu, Influence of agitation rate and dissolved oxygen tension on the production of gellan by Sphingomonas paucimobilis, Procd. Indian Pharmaceutical Congress, 302, 2005.

8. R. M. Banik, Mayank, A. Santhiagu, D. K. Pandey, S. K. Pandey, Oxygen electrode based microbial sensor for quick, specific and sensitive quantification of nitrophenolic compound, Procd. Association of Microbiologist of India, 18, 2005.

9. R. M. Banik, Mayank, A. Santhiagu, D. K. Pandey, S. K. Pandey, Microbial production of alkaline phosphatase using batch mode fermentation, Procd. Association of Microbiologist of India, 101, 2005.

10. A. Santhiagu, R.M. Banik, Response surface methodology for gellan gum production by Sphingomonas paucimobilis with non-ionic surfactants. Procd. International conference on Recent Trends in Biotechnology, 54, 2007

11. A. Santhiagu, R.M. Banik, Effect of addition of antibiotics on the production of gellan by Sphingomonas paucimobilis. Procd. International Conference on Recent Trends in Biotechnology, 93, 2007.

12.  A. Santhiagu, R.M. Banik, Development of mathematical model for gellan production by Sphingomonas paucimobilis. Procd. International Conference on Recent Trends in Biotechnology, 96, 2007.

13. Jaya Prakash S, Yuvaraja K. R, and Santhiagu A. Homology modeling of GelF gene from gellan gum producing bacterial strain Sphingomonas elodea ATCC 31461; International Conference on Biotechnology and Bioinformatics; 2014: p- 72.

14. Jaya Prakash S, Yuvaraja K. R, and Santhiagu A. Development and In vitro evaluation      of novel gellan gum- raloxifene nanoparticles for oral drug delivery; International Conference on Biotechnology and Human Welfare; 2013: p- 87.

15. Yuvaraja K. R., Jaya prakash S., and Santhiagu A. Antioxidant and hepatoprotective activity of hydnocarpus larifolia against paracetamaol induced liver damage in rats; International Conference on Biotechnology and Human Welfare; 2013: p-109.

16. Divya Ayyanari., Jaya Prakash Shanmugam., and Arockiasamy Santhiagu. Cloning and expression of a highly active recombinant alkaline phosphatase from Bacillus licheniformis MTCC1483; International Conference on Chemical and Bioprocess Engineering; 2013: p- 88.

17. Vidhuna Sadanandan and Arockiasamy Santhiagu. Isolation of a novel ribonuclease producing soil bacteria and medium optimization for enhanced nuclease production using Plackett Burman design and Central Composite design; International Conference on Chemical and Bioprocess Engineering; 2013: p- 89.

18. K. R. Yuvaraja., S. Jaya prakash., and A. Santhiagu. Antioxidant and hepatoprotective activity of Dipteracanthus patulus (Jacq.) Nees (Acanthaceae) against paracetamol induced liver damage in rats; National conference on phytomedicine; 2012: p- 128.

19. K Joji and A Santhiagu. Screening, isolation and characterization of a novel fibrinolytic enzyme from marine Bacillus SKA2712; International conference on contemporary research trends in diagnostics and therapeutics;2015.

20. S Nisha and A Santhiagu. Isolation and Identification of methioninase producing fungi from soil; International conference on contemporary research trends in diagnostics and therapeutics;2015.

21.   A. Divya and A Santhiagu. Partitioning studies of alkaline phosphatase from recombinant Escherichia coli BL21 (DE3) using aqueous two phase systems; International conference on contemporary research trends in diagnostics and therapeutics;2015.

22. Nisha salim and A Santhiagu. Kinetic charecterization of L-methioninasefrom Trichodermaharzianum CEN 439; International conference on innovations in pharma and biopharma industry; 2017 

23.  K Joji and A Santhiagu . Optimization of Medium Components by Statistical Methods for Enhanced Production of Fibrinolytic Enzyme by Bacillus sp. SKA27; International Conference on Innovations in Pharma and biopharma industry; 2017.

24. Manjusha CM, Santhiagu A,Adarsh VK, Jaya Prakash S. Homology modeling of gel Q gene from gellan gum producing bacterial strain Sphingomonas elodea ATCC 31461using Phyre2 and I-Tasser; International Conference on Innovations in Pharma and Biopharma Industry;2017.

25. Soumiya S, Santhiagu A, Adarsh VK, Jaya Prakash S. Homology Modeling and Model   Validation of GEL E from gellan gum producing bacterial strain Sphingomonas elodea ATCC 31461; International Conference on Innovations in Pharma and Biopharma Industry;2017.

26. Adarsh VK,A Santhiagu ,Jobin Ravi .Analysis of synonymous codon usage of Seryl tRNA synthetase gene of Mycobacterium tuberculosis H37Rv; codon optimization and prediction of heterologous expression level. International conference-cum-workshop on Informatics Tools in Drug Discovery and Drug Delivery;2018

27.  Adarsh VK,A Santhiagu ,Jobin Ravi .Computational Subtractive Genomics  and Gene Expression studies approach for the identification of novel drug targets IN Mycobacterium tuberculosis; International Conference on Academic and Industrial Innovations: Transitions in Pharmaceutical, Medical and Biosciences;2018 

28. Soumiya S, Santhiagu A, Adarsh VK, Jaya Prakash S. Homology Modelling of GEL C gene from gellan gum producing bacterial strain Sphingomonas elodea ATCC31461 and StructuralValidation; Bioengineering on Health and Environment (ICBHE);2018.

29. Manjusha CM, Santhiagu A, Adarsh VK, Jaya Prakash S. Phyre2 and I-Tasser protein modeling of gel K gene from gellan gum producing bacterial strain Sphingomonas elodea ATCC 31461; Bioengineering on Health and Environment (ICBHE);2018.

30. Manjusha CM, Santhiagu A, Adarsh VK, Jaya Prakash S. Comparative study on homology modeling of gel L gene from gellan gum producing bacterial strain Sphingomonas elodea ATCC 31461 using Phyre2 and I-Tasser; 30th Kerala Science Congress;2018.

31. Soumiya S,  A.Santhiagu and Adarsh V.K. Homology Modeling of GEL D gene from gellan gum producing bacterial strain Sphingomonas elodea ATCC 31461 and Structural Validation. 30th Kerala Science Congress;2018.

32.  Jobin Ravi,Adarsh VK,A Santhiagu. Identification of selective inhibitors of vegfr-2 using e- pharmacophore mapping with virtual screening and molecular docking studies ;International conference on clinical pharmacy & pharmaceutical technology ;2019.

33. Soumiya Sukumar, Santhiagu Arockiasamy and Manjusha Chemmattu Moothona. Erlotinib loaded gellan gum nanoparticles: Synthesis, characterization, in vitro drug release and cytotoxicity studies;  International scientific seminar on pharmacy profession and its Social Commitment by Kerala state Pharmacy council;2019.

34. K.R. Yuvaraja, K. Aswin, and A. Santhiagu .Antioxidant and hepatoprotective of Hydnocarpus laurifolia An in vitro and in vivo evoluation; SKM National Seminar on Management of Life style disorders ;2019.

35. K. Gopalasatheeskumar, K. R. Yuvaraja and A. Santhiagu.Hepatoprotective activity of Ehretia microphylla extract and characterization of its phytoconstituents;6th International Congress of the Society for Ethnopharmacology;2019.

Completed PhDs

Jayaprakash S

Divya A

Saravana Perumal P

Nisha Salim

Students Ongoing

Yuvaraja K R

Joji K

Adarsh VK

Manjusha CM

Soumiya S

Jobin Ravi

Bioprocess Technology

• Microbial production of enzymes, antibiotics, biopolymers, vitamins and bio-chemicals

• Development of recombinant microbial strains for enhanced bio-production

• Modeling and simulation of bioprocesses

• Development of biosensors for the quantification of toxic phenolic compounds, organophosphates and physiologically important bio-molecules

• Bioremediation - removal of toxic elements using microbes

• Controlled drug delivery systems - modification of polymers for controlled drug delivery

• Gene isolation and characterization

• Drug Design and development

• Identification of new drug targets and its drug like inhibitors by the computational approaches - Subtractive genomics, Gene expression studies and computer aided drug discovery (CADD).

Awarded  “Rashtriya Gaurav Award” by IIFS, New Delhi for the contribution to scientific development and social work

Reviewer of the International Journal - Applied Microbiology and Biotechnology - published by Springer.

Reviewer of the International Journal - Process Biochemistry - published by Elsevier.

Reviewer of the International Journal “Journal of Bioscience and Bioengineering” published by Elsevier.

Qualified Graduate Aptitude Test in Engineering (GATE-1999) with All India Rank-50 in Pharmaceutical Sciences

Best Major B.Tech Projects (2016-17)    

Homology Modelling and validation of Mycobacterium tuberculosis seryl tRNA synthase

Best Paper

1. Manjusha CM, Santhiagu A, Adarsh VK, Jaya Prakash S. Phyre2 and I-Tasser protein modeling of gel K gene from gellan gum producing bacterial strain Sphingomonas elodea ATCC 31461; Bioengineering on Health and Environment (ICBHE);2018

2. Soumiya Sukumar, Santhiagu Arockiasamy and ManjushaChemmattuMoothona. Erlotinib loaded gellan gum nanoparticles:Synthesis, characterization, in vitro drug release and cytotoxicity studies;  International scientific seminar on pharmacy profession and its Social Commitment by Kerala state Pharmacy council;2019.

Best Poster

1. Jobin Ravi, Adarsh VK,A Santhiagu. Identification of selective inhibitors of vegfr-2 using e- pharmacophore mapping with virtual screening and molecular docking studies ;International conference on clinical pharmacy & pharmaceutical technology ;2019.

1. Convenor of National Conference on Emerging Concepts in Biotechnology (ECB-2009) held during December 11 -12, 2009 at NIT Calicut

2. Convenor of International Conference on Genomics and Proteomics (ICGP-2011) held during July 14 -16, 2011 at NIT Calicut

• UGC Junior Research Fellowship (1999-2001)

• UGC Senior Research Fellowship (2002-2006)

Delivered a guest lecture on the topic-Biodegradable polymers-at Kamaraj College of Engineering, Virudhunagar, Tamil Nadu

Title: Studies on Fermentative Production of Gellan Gum by recombinant Sphingomonas paucimobilis strain: Characterization and Application in Sustained Drug Delivery Systems
Funding Agency: Department of Biotechnology (DBT), Ministry of Science and Technology, New Delhi
Amount: 21.98 lakhs

Title: Development of an extractive fermentation process for enhanced alkaline phosphatase production by recombinant Bacillus licheniformis in aqueous two-phase systems
Funding Agency: Department of Science and Technoogy (DST), Ministry of Science and Technology, New Delhi
Amount: Rs. 18.32 lakhs

Title: Development of a low cost extractive fermentation process in aqueous two phase systems for gellan hydrolyzing enzyme production
Funding Agency: Council of Scientific and Industrial Research (CSIR), New Delhi
Amount: 13.00 lakhs.

Life Member, Biotech Research Society of India