Dr. K. Gopal Shankar
Dr. K. Gopal Shankar

Assistant Professor

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  • B.Tech, Biotechnology, VIT University, India, 2005-2009

  • MSc (M.Tech), Biotechnology, Chalmers University, Sweden, 2009-2011

  • Ph.D (Biomedical Sciences), ITN, Marie Curie Fellow, University of Bologna, Italy, 2014-2017

  • Journals

    B. Subramanian, P. Sasikumar, S. Thanka Rajan, K. Gopal Shankar, Murugan Veerapandian, Fabrication of Zr-Ti-Si glassy metallic overlay on 3D printed Ti-6Al4V implant prototypes for enhanced biocompatibility,Journal of Alloys and Compounds, 2023, 170933. (IF-6.3)

    Sivaranjani S, Thampi VA, Shalini M, Shankar KG, Veerapandian M, Shtansky D, Subramanian B. Imparting bioactivity to CP− Titanium with sputtered TiBN interlayer and electrophoretically grown bioglass overlay. Materials Chemistry and Physics. 2023, 127420. (IF-4.7)

    Thirupathi, Kokila, Chaitany Jayaprakash Raorane, Vanaraj Ramkumar, Selvakumari Ulagesan, Madhappan Santhamoorthy, Vinit Raj, Gopal Shankar Krishnakumar, Thi Tuong Vy Phan, Seong-Cheol Kim. Update on Chitosan-Based Hydrogels: Preparation, Characterization, and Its Antimicrobial and Antibiofilm Applications. Gels, 9(1), 35, 2023. (IF-4.4)

    Muthusamy S, Mahendiran B, Nithiya P, Selvakumar R, Krishnakumar GS. Functionalization of biologically inspired scaffold through selenium and gallium ion doping to promote bone regeneration. Journal of Drug Delivery Science and Technology. 2022 Nov 24:104011. (IF – 5.0)

    Mahendiran B, Muthusamy S, Sampath S, Jaisankar SN, Selvakumar R, Krishnakumar GS. In vitro and in vivo biocompatibility of decellularized cellulose scaffolds functionalized with chitosan and platelet rich plasma for tissue engineering applications.   Int J Biol Macromol, 217, 2022, 522-535. (IF – 8.0)

    Mahendiran B, Muthusamy S, Janani G, Mandal BB, Rajendran S, Krishnakumar GS. Surface Modification of Decellularized Natural Cellulose Scaffolds with Organosilanes for Bone Tissue Regeneration. ACS Biomat Sci & Eng, 8(5),2000-2015, 2022 (IF – 5.3)

    MA Grimaudo, GS Krishnakumar, E Giusto, F Furlani, G Bassi, A Rossi, F Molinari, F Lista, M Montesi, S Panseri. Bioactive injectable hydrogels for on demand molecule/cell delivery and for tissue regeneration in the central nervous system. Acta Biomateriala, 2021, 140, 88-101 (IF – 10.6)

    PB Sathish, S Gayathri, J Priyanka, Shalini Muthusamy, R Narmadha, Gopal Shankar Krishnakumar, R Selvakumar. Tricomposite gelatin-carboxymethylcellulose-alginate bioink for direct and indirect 3D printing of human knee meniscal scaffold. Int J Biol Macromol. 2021, 195, 179-189. (IF – 8.0)

    Mahendiran B, Muthusamy S, Narmada R, Sampath S, Jaisankar SN, Selvakumar R, Krishnakumar GS. Decellularized natural 3D cellulose scaffold derived from Borassus flabellifer (Linn.) as extracellular matrix for tissue engineering applications. Carbohydrate Polymers.2021,272,118494.  (IF – 10.7)

    Muthusamy S, Mahendiran B, Sampath S, Jaisankar SN, Anandasadagopan SK, Krishnakumar GS. Hydroxyapatite nanophases augmented with selenium and manganese ions for bone regeneration: Physiochemical, microstructural and biological characterization. Mater Sci Eng C Mater Biol Appl. 2021, 126, 112149. (IF – 7.3)

    Mahendiran B, Muthusamy S, Sampath S, Jaisankar SN, Popat KC, Selvakumar R, Krishnakumar GS. Recent trends in natural polysaccharide based bioinks for multiscale 3D printing in tissue. Int J Biol Macromol. 2021, 183, 564-588. (IF – 8.0)

    Mariani E, Roffi A, Cattini L, Pulsatelli L, Assirelli E, Krishnakumar GS, Cenacchi A, Kon E, Filardo G. Release Kinetic of Pro- And Anti-Inflammatory Biomolecules From Platelet-Rich Plasma and Functional Study on Osteoarthritis Synovial Fibroblasts. Cytotherapy. 2020, 22(7), 344-353. (IF – 5.4)

    Krishnakumar GS, Balaji Mahendiran, Subiksha Gopalakrishnan, Shalini Muthusamy, Sinduja Malarkodi Elangovan. Honey based treatment strategies for infected wounds and burns: A systematic review of recent pre-clinical research. Wound Medicine. 2020, 30, 100188. (IF – Nil)

    Krishnakumar GS, Sampath S, Muthusamy S, John MA, Importance of crosslinking strategies in designing smart biomaterials for bone tissue engineering: A systematic review. Mater Sci Eng C Mater Biol Appl. 2019, 96, 941-954. (IF – 7.3)

    Krishnakumar GS, Gostynska N, Dapporto M, Campodoni E, Montesi M, Panseri S, Tampieri A, Kon E, Marcacci M, Sprio S, Sandri M. Evaluation of different crosslinking agents on hybrid biomimetic collagen-hydroxyapatite composites for regenerative medicine. Int J Biol Macromol. 2018 ,106, 739-748. (IF – 8.0)

    Udhayakumar S, Shankar KG, Sowndarya S, Rose C. Novel fibrous collagen-based cream accelerates fibroblast growth for wound healing applications: in vitro and in vivo evaluation. Biomater Sci. 2017, 5(9), 1868-1883. (IF – 7.5)

    Sivalingam Udhayakumar, Krishnakumar GS, Sampath Sowndarya, SankarVenkatesh,  Chellappa Muralidharan, Chellan Rose. L-Arginine intercede Bio-Crosslinking of Collagen-Chitosan 3D-Hybrid Scaffold for Tissue Engineering and Regeneration: an in silico, in vitro, and in vivo studies. RSC Advances. 2017, 7 (40), 25070-25088. (IF – 4.0)

    Krishnakumar GS, Roffi A, Reale D, Kon E, Filardo G. Bone Morphogenic Protein augmentation for long bone healing" response to Clinical need for bone morphogenetic protein . Int. Orthop. 2017, 41(11):2417-2419. (IF – 3.0)

    Roffi A, Krishnakumar GS, Gostynska N, Kon E, Candrian C, Filardo G. The Role of Three-Dimensional Scaffolds in Treating Long Bone Defects: Evidence from Preclinical and Clinical Literature-A Systematic Review. Biomed Res Int. 2017, 8074178. (IF – 3.2)

    Sampath S, Veeramani V, Krishnakumar GS, Sivalingam U, Madurai SL, Chellan R. Evaluation of in vitro anticancer activity of 1,8-Cineole-containing n-hexane extract of Callistemon citrinus (Curtis) Skeels plant and its apoptotic potential. Biomed Pharmacother. 2017, 93, 296-307. (IF – 7.4)

    Gostynska N, Krishnakumar GS, Campodoni E, Panseri S, Montesi M, Sprio S, Kon E, Marcacci M, Tampieri A, Sandri M. 3D porous collagen scaffolds reinforced by glycation with ribose for tissue engineering application. Biomed Mater. 2017, 12(5):055002. (IF – 4.1)

    Krishnakumar GS, Gostynska N, Campodoni E, Dapporto M, Montesi M, Panseri S, Tampieri A, Kon E, Marcacci M, Sprio S, Sandri M. Ribose mediated crosslinking of collagen-hydroxyapatite hybrid scaffolds for bone tissue regeneration using biomimetic strategies. Mater Sci Eng C Mater Biol Appl. 2017, 77, 594-605. (IF – 7.3)

    Krishnakumar GS, Roffi A, Reale D, Kon E, Filardo G. Clinical application of bone morphogenetic proteins for bone healing: a systematic review .Int Orthop. 2017, 41(6), 1073-1083. (IF – 3.0)

    Roffi A, Di Matteo B, Krishnakumar GS, Kon E, Filardo G. Platelet-rich plasma for the treatment of bone defects: from pre-clinical rational to evidence in the clinical practice. A systematic review. Int Orthop. 2017, 41(2), 221-237. (IF – 3.0)

    Krishnakumar GS, Gostynska N, Montesi M, Panseri S, Sprio S, Kon E, Marcacci M, Tampieri A, Sandri M. Investigation of different cross-linking approaches on 3D gelatin scaffolds for tissue engineering application: A comparative analysis. Int J Biol Macromol. 2017, 95, 1199-1209. (IF – 8.0)

    Gopal Shankar K, Udhaya Kumar S, Sowndarya S, Suresh Babu P, Rose C. Isolation, characterization, and in vitro evaluation of bovine rumen submucosa films of collagen or chitosan-treated collagen. J Biomater Appl. 2016, 30(6), 780-92. (IF – 2.7)

    Gopal Shankar K, Udhaya Kumar S, Sowndarya S, Soniya Angel, P, Rose C. Rumen tissue derived decellularized submucosa collagen or its chitosan-treated film as a cutaneous wound healant and 1H NMR-metabolite profiling of plasma. RSC Advances, 2016, 6, 107403. (IF – 4.0)

    Books (Refereed)

    Mahendiran B, Abdul Azeez N, Muthusamy S, Krishnakumar GS, Polymer-Based Nanomaterials for Targeted Drug Delivery, Fundamentals of BioNanomaterials, 2022, 241-271, Elsevier, eBook ISBN: 9780128241486

    Mahendiran B., Muthusamy S., Sampath S., Jaisankar S.N., Krishnakumar G.S. (2021) Nanocelluloses for Tissue Engineering Application. In: Barhoum A. (eds) Handbook of Nanocelluloses. Springer.

    Professional Experience

    • Assistant Professor, Department of Biotechnology, PSG Institute of Advanced studies, Coimbatore, India, 2019-2023

    • Assistant Professor, Department of Biotechnology, Bannari Amman Institute of Technology, Erode, India, 2017-2019

    • Junior Research Fellow, Department of Biotechnology, CSIR-Central Leather Research Institute, Chennai, India, 2012-2014

    Educational Qualifications

    • B.Tech, Biotechnology, VIT University, India, 2005-2009

    • MSc (M.Tech), Biotechnology, Chalmers University, Sweden, 2009-2011

    • Ph.D (Biomedical Sciences), ITN, Marie Curie Fellow, University of Bologna, Italy, 2014-2017

    Received TNSCST Student project under science stream of Rs. 10,000 for the year 2018- 2019 – Completed - Doping of manganese and selenium ions in a biologically inspired scaffold to biomimic the osteogenic niches for bone regeneration - PI

    Received DST-SERB Start up research grant of Rs.24,87,595 for the year 2020- 2022 – Completed - Novel strategies in green synthesis of smart, biomimetic scaffolds bio-functionalized with growth factors for meniscus regeneration - PI

    Received DST-SERB Seminar/Symposium grant of Rs.2,00,000 for the year 2023-2024 for conducting International Conference and Start Up Summit on Functional Biomaterials & Synthetic Biology FBSB-2023 – Convener

    A process for the preparation of a collagenous biomaterial for medical applications - Indian patent application no: 2736DEL2014 – Granted (Patent No:361781)

    Collagenous cream composition for biomedical application and a process for the preparation thereof – Indian patent application no: 3554DEL2015 – Granted (Patent No:428383)

    Awarded Indian National Science Academy (INSA) Visiting Scientist Award for the year 2023-2024

    Awarded Marie Curie fellowship from ITN-European Consortium to pursue my Ph.D degree at Rizzoli Hospital, University of Bologna, 2014-2017, Italy.

    Participated and won the young scientist award at CSIR-CLRI foundation day programme, 2012, Chennai, India

    Awarded FELASA B, Introductory course on animal science (Theoretical and practical workshop), 2017, Berlin, Germany

    Awarded Young scientist award, Marina labs, 2017, Chennai, India

    Biomedical materials

    Bioceramics & biocomposites

    Cell biomaterials studies (In vitro & In vivo)

    Tissue engineering & Regenerative medicine 

    Stem cell biology

    3D Bioprinting